Plasma levels of vascular endothelial growth factor and its soluble receptor in non-alcoholic fatty liver disease

Authors

  • Ali Bahari Gastroenterology and Hepatology Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Farkhonde Razmpour Department of Clinical Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mahsa Tousi Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohsen Azimi-Nezhad Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohsen Nematy Department of Nutrition, School of Medicine, Biochemistry and Nutrition, Endoscopic & Minimally Invasive Surgery, and Cancer Research Centers, Mashhad University of Medical Sciences (MUMS), Paradise Daneshgah, Azadi Square, Mashad, Iran
  • Zahra Dehnavi Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a clinical pathologic condition, which leads to inflammation events in hepatocytes. The objective of present study was to compare the plasma levels of VEGF and sVEGFR-1 as inflammation factors in overweight and obese children and adolescents with and without NAFLD. Materials and Methods: A total sample of 70 overweight and obese children and adolescents (37 boys and 33 girls) were recruited from those admitted to a nutrition clinic in Mashhad, northeastern Iran. The presence of NAFLD was determined by FibroScan, ultrasound and elevation of liver enzyme. Plasma VEGF and sVEGFR1 were also determined for each individual. Results: VEGF levels (log transformed) showed a significant stepwise increase from “zero” to “first”, “second” and “third” grades (P trend

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Journal title

volume 6  issue 2

pages  107- 114

publication date 2018-12-16

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